Ximing Guo
(856) 785-0074 x4324
Mailing Address:
  Haskin Shellfish Research Laboratory
  6959 Miller Avenue
  Port Norris, NJ 08349 USA


Ph.D. 1991 University of Washington (Seattle)
M.S. 1987 University of Washington (Seattle)
B.S. 1983 Ocean University of China (Qingdao)


Research Interests

My research is on the genetics and reproduction of marine molluscs.  I am interested in genetic mechanisms of molluscan development and reproduction, and their applications in the improvement of cultured molluscs. Currently, research in my lab is focused on three areas: 1) selective breeding for disease-resistance and superior growth; 2) the development of triploids, tetraploids and other genetic constructs that are important for aquaculture and genetic analyses; and 3) genomic studies towards a better understanding of the genome organization and inheritance of economically important traits. I am also interested in mechanisms of genome evolution and the involvement of meiosis, sex and chromosomal changes.

Click here to download my Curriculum Vitae


Current Research Projects

• Advancing eastern oyster aquaculture through marker-assisted selection. (NOAA NJ Sea Grant)

• Development of a theoretical basis for modeling disease processes in marine invertebrates. (National Science Foundation EEID)

• Genetic marker-assisted selection of northeastern hard clams for QPX resistance. (USDA/NRAC with SBU)

• Improving shellfish survival through genetic improvement in disease resistance. (USDA/ARS with URI)

• Genetic markers of resistance to oyster herpes virus infection in the Pacific Oyster, Crassostrea gigas (University of Caen, Lower Normandy, France)

• International oyster genome project (in collaboration with the Institute of Oceanology Chinese Academy of Sciences and BGI)



Selected Publications

Zhang, L., L. Li, Y. Zhu, G. Zhang and X. Guo. 2013. Transcriptome analysis reveals a rich gene set related to innate immunity in the eastern oyster (Crassostrea virginica). Marine Biotechnology. DOI: 10.1007/s10126-013-9526-z.

Zhang, G., X. Fang, X. Guo, L. Li, R. Luo, F. Xu, et al (80). 2012. The oyster genome reveals stress adaptation and complexity of shell formation. Nature, 490:49-54. DOI: 10.1038/nature11413.

He, Y., H. Yu, Z. Bao, Q. Zhang and X. Guo. 2012. Mutation in promoter region of a serine protease inhibitor confers Perkinsus marinus resistance in the eastern oyster (Crassostrea virginica). Fish & Shellfish Immunology 33: 411-417.

Ren, J., X. Liu, F. Jiang, X. Guo and B Liu. 2010. Unusual conservation of mitochondrial gene order in Crassostrea oysters: evidence for recent speciation in Asia. BMC Evolutionary Biology, 10:394.

Wang, H., L. Qian, X. Liu, G. Zhang and X. Guo. 2010. Classification of a common cupped oyster from southern China. J. Shellfish Res., 29(4):857-866.

Zhang, L. and X. Guo. 2010. Development and validation of single nucleotide polymorphism markers in the eastern oyster Crassostrea virginica Gmelin by mining ESTs and resequencing. Aquaculture, 302:124-129.

Guo, X., Y. Wang, Z. Xu and H. Yang. 2009. Chromosome set manipulation in shellfish. Pp 165 – 195 in: New Technologies in Aquaculture: Improving Production Efficiency, Quality and Environmental management, G. Burnell and G. Allan (eds). Woodhead Publishing.

Guo, X. 2009. Use and exchange of genetic resources in molluscan aquaculture. Reviews in Aquaculture 1:251–259.

Hofmann, E, D. Bushek, S. Ford, X. Guo, D. Haidvogel, D. Hedgecock, J. Klinck, C. Milbury, D. Narvaez, E. Powell, Y. Wang, Z. Wang, J. Wilkin and L. Zhang. 2009. Understanding how disease and environment combine to structure resistance in estuarine bivalve populations. Oceanography, 22(4):212-231.

Wang, Y., Y. Shi and X. Guo. 2009. Identification and characterization of 66 EST-SSR markers in the eastern oyster Crassostrea virginica (Gmelin). J. Shellfish Res., 28(2):227-234.

Ren, J., X. Liu, G. Zhang, B. Liu and X. Guo. 2009. “Tandem duplication-random loss” is not a real feature of oyster mitochondrial genomes. BMC Genomics, 10:84.

Wang, H. and X. Guo. 2008. Identification of Crassostrea ariakensis and related oysters by multiplex species-specific PCR. J. Shellfish Res., 27(3):481-487.

Wang, Y. and X. Guo. 2008. ITS length polymorphism in oysters and its potential use in species identification. J. Shellfish Res., 27(3):489-493.

Guo, X., Y. Wang, L. Wang and J-H Lee. 2008. Oysters. Pp 161 – 175 in: Genome Mapping and Genomics in Fishes and Aquatic Animals, Thomas D. Kocher & Chittaranjan Kole (Eds), Springer, Berlin.

Guo, X., Y. Wang and Z. Xu. 2007. Genomic analyses using fluorescent in situ hybridization. In: Aquaculture Genome Technologies, Zhanjiang (John) Liu (ed), Blackwell Publishing, Ames, pp. 289-311.

Wang, Y. and X. Guo. 2007. Development and characterization of EST-SSR markers in the eastern oyster Crassostrea virginica. Marine Biotechnology, 9, 500–511.

Yu, Z. and X. Guo. 2006. Identification and mapping of disease-resistance QTL in the eastern oyster, Crassostrea virginica Gmelin. Aquaculture, 254:160-170.

Wang, Y., Z. Xu. J.C. Pierce and X. Guo. 2005. Characterization of eastern oyster (Crassostrea virginica Gmelin) chromosomes by fluorescence in situ hybridization with bacteriophage P1 clones. Marine Biotechnology, 7:207-214.

Wang, Y. and X. Guo, 2004. Chromosomal rearrangement in Pectinidae revealed by rRNA loci and implications for bivalve evolution. Biol. Bull., 207:247-256.

Tanguy, A., X. Guo and S.E. Ford. 2004. Discovery of genes expressed in response to Perkinsus marinus challenge in eastern (Crassostrea virginica) and Pacific (C. gigas) oysters. Gene, 338:121-131.

Yu, Z. and X. Guo. 2003. Genetic linkage map of the eastern oyster Crassostrea virginica Gmelin. Biol. Bull. 204: 327–338.

Guo, X., D. Hedgecock, W.K. Hershberger, K. Cooper and S.K. Allen, Jr.  1998. Genetic determinants of protandric sex in Crassostrea oyster.  Evolution, 52(2):394-402.

Guo, X., G. DeBrosse and S.K. Allen, Jr. 1996.  All-triploid Pacific oysters (Crassostrea gigas Thunberg) produced by mating tetraploids and diploids.  Aquaculture, 142:149-161.



Courses Taught

Aquaculture, 11:628:317


Current Students

Na Zhang, Ph.D. student, working genetic mechanisms of sex determination in oysters.

Jun Liu, Ph.D. student, working on apoptosis regulation in stress response in oysters.

Cui Li, Ph.D. student, working on evolution and adaptation of molluscs.


Current Postdocs

Dr. Ming Liu, working on genetics of disease-resistance in oysters

Visiting Scientists

Dr. Weihong Zhao, visiting scientist, Yancheng Institute of Technolohy (China), working on shellfish genetics and reproduction.

[Haskin Shellfish Research Laboratory]