Ximing Guo
(856) 785-0074 x4324
Mailing Address:
  Haskin Shellfish Research Laboratory
  6959 Miller Avenue
  Port Norris, NJ 08349 USA


Ph.D. 1991 University of Washington (Seattle)
M.S. 1987 University of Washington (Seattle)
B.S. 1983 Ocean University of China (Qingdao)


Research Interests

My research is on the genetics and reproduction of marine molluscs. I am interested in genetic mechanisms of molluscan development and reproduction, and their applications in the improvement of cultured molluscs. Currently, research in my lab is focused on three areas: 1) selective breeding for disease resistance and superior growth in cultured molluscs; 2) the development of triploids, tetraploids and other genetic constructs that are important for aquaculture and genetic analyses; and 3) genomic studies towards a better understanding of bivalve biology, adaptation and inheritance of economically important traits. I am also interested in mechanisms of genome evolution and the involvement of meiosis, sex and chromosomal changes.

Click here to download my Curriculum Vitae


Current Research Projects

•Enhancing bivalve aquaculture through species improvement and diversification. (NOAA Sea Grant)

•Validation of markers and marker-assisted selection of hard clam for resistance to QPX disease (USDA NIFA with SBU)

•Improving shellfish survival through genetic improvement in disease resistance. (USDA Hatch and NJAES)

•Advancing eastern oyster aquaculture through marker-assisted selection. (NJ Sea Grant and NJAES)

•Gene editing through CRISPR/Cas-9 (Rutgers NJAES)


Selected Publications

Liu, M., & X. Guo. (2017). A novel and stress adaptive alternative oxidase derived from alternative splicing of duplicated exon in oyster Crassostrea virginica. Scientific Reports, 7, 10785. DOI: 10.1038/s41598-017-10976-w.

Guo, X., & S. E. Ford. (2016). Infectious diseases of marine molluscs and host responses as revealed by genomic tools. Philosophical Transactions of the Royal Society B, 371 (1689), 20150206. DOI: 10.1098/rstb.2015.0206.

Guo, X., Y. He, L. Zhang, C. Lelong, & A. Jouaux. (2015). Immune and stress responses in oysters with insights on adaptation. Fish & Shellfish Immunology, 46 (1), 107-119. DOI: 10.1016/j.fsi.2015.05.018.

He, Y., A. Jouaux, S. E. Ford, C. Lelong, P. Sourdaine, M. Mathieu, & X. Guo. (2015). Transcriptome analysis reveals strong and complex antiviral response in a mollusc. Fish & Shellfish Immunology, 46 (1), 131-144. DOI: 10.1016/j.fsi.2015.05.023.

Zhang, N., F. Xu, & X. Guo. (2014). Genomic analysis of the Pacific oyster (Crassostrea gigas) reveals possible conservation of vertebrate sex determination in a Mollusc. G3: Genes, Genomes, Genetics, 4 (11), 2207-2217. DOI: 10.1534/g3.114.013904.

Zhang, G., X. Fang, X. Guo, L. Li, R. Luo, F. Xu, et al. (80). (2012). The oyster genome reveals stress adaptation and complexity of shell formation. Nature, 490, 49-54. DOI: 10.1038/nature11413.

He, Y., H. Yu, Z. Bao, Q. Zhang, & X. Guo. (2012). Mutation in promoter region of a serine protease inhibitor confers Perkinsus marinus resistance in the eastern oyster (Crassostrea virginica). Fish & Shellfish Immunology 33 (2), 411-417. DOI: 10.1016/j.fsi.2012.05.028.

Wang, Y., X. Wang, A. Wang, & X. Guo. (2010). A 16-microsatellite multiplex assay for parentage assignment in the eastern oyster (Crassostrea virginica). Aquaculture, 308, S28-S33. DOI: 10.1016/j.aquaculture.2010.05.037.

Zhang, L., & X. Guo. (2010). Development and validation of single nucleotide polymorphism markers in the eastern oyster Crassostrea virginica Gmelin by mining ESTs and resequencing. Aquaculture, 302 (1-2), 124-129. DOI: 10.1016/j.aquaculture.2010.02.012.

Guo, X., Y. Wang, Z. Xu, & H. Yang. (2009). Chromosome set manipulation in shellfish. In G. Burnell & G. Allan (Eds.), New Technologies in Aquaculture: Improving Production Efficiency, Quality and Environmental management (pp. 165-195). Great Abington, Cambridge: Woodhead Publishing. DOI: 10.1533/9781845696474.1.165.

Guo, X. (2009). Use and exchange of genetic resources in molluscan aquaculture. Reviews in Aquaculture, 1, 251-259. DOI: 10.1111/j.1753-5131.2009.01014.x.

Guo, X., Y. Wang, L. Wang, & J-H Lee. (2008). Oysters. In Thomas D. Kocher & Chittaranjan Kole (Eds.), Genome Mapping and Genomics in Fishes and Aquatic Animals (pp. 161-195). Berlin Heidelberg: Springer-Verlag. DOI: 10.1007/978-3-540-73837-4_8.

Guo, X., Y. Wang, & Z. Xu. (2007). Genomic analyses using fluorescent in situ hybridization. In Zhanjiang (John) Liu (Ed.), Aquaculture Genome Technologies (pp. 289-311). Ames, IA: Blackwell Publishing Ltd. DOI: 10.1002/9780470277560.ch17.

Yu, Z., & X. Guo. (2006). Identification and mapping of disease-resistance QTL in the eastern oyster, Crassostrea virginica Gmelin. Aquaculture, 254, 160-170. DOI: 10.1016/j.aquaculture.2005.10.016.

Tanguy, A., X. Guo, & S. E. Ford. (2004). Discovery of genes expressed in response to Perkinsus marinus challenge in eastern (Crassostrea virginica) and Pacific (C. gigas) oysters. Gene, 338, 121-131. DOI: 10.1016/j.gene.2004.05.019.

Yu, Z., & X. Guo. (2003). Genetic linkage map of the eastern oyster Crassostrea virginica Gmelin. Biololgical Bulletin, 204, 327-338. DOI: 10.2307/1543603.

Guo, X., S. E. Ford, & F. Zhang. (1999). Molluscan aquaculture in China. Journal of Shellfish Research, 18 (1), 19-31.

Guo, X., D. Hedgecock, W. K. Hershberger, K. Cooper, & S. K. Allen, Jr. (1998). Genetic determinants of protandric sex in Crassostrea oyster. Evolution, 52 (2), 394-402. DOI: 10.1111/j.1558-5646.1998.tb01640.x.

Guo, X., G. DeBrosse, & S. K. Allen, Jr. (1996). All-triploid Pacific oysters (Crassostrea gigas Thunberg) produced by mating tetraploids and diploids. Aquaculture, 142, 149-161. DOI: 10.1016/0044-8486(95)01243-5.

Guo, X., & S. K. Allen, Jr. (1994). Viable tetraploid Pacific oyster (Crassostrea gigas Thunberg) produced by inhibiting polar body I in eggs from triploids. Molecular Marine Biology Biotechnology, 3 (1), 42-50. ResearchGate.


Courses Taught

Aquaculture, 11:628:317


Current Students

Michael Whiteside, M.S. student, working on genetics of shell color and shape in the eastern oyster.

Zhenwei Wang, Ph.D. student, working on gene editing using CRISPR/Cas-9 in marine bivalves.


Current Postdocs

Shubo Jin, working on oyster genetics and genomics.

Visiting Scientists

Jianyong Liu, Professor and Visiting Scientist, Guangdong Ocean University, working on shellfish genetics and breeding.

Qingheng Wang, Associate Professor and Visiting Scientist, Guangdong Ocean University, working on shellfish genetics and aquaculture.

[Haskin Shellfish Research Laboratory]